Media & Publications

Koshi Online

May 16, 2025

Prof. Dr. Jha wins ‘Three Qin Friendship’ award in China

The Shaanxi Provincial Government of China is to present the “Three Qin Friendship Award” for the year 2022 to Nepali professor Dr. Rajiv Kumar Jha.

The award is the highest award established by the provincial government to commend foreign experts who have made outstanding contributions to the economic and social development of Shaanxi.

Nepali organization selected for research in China

Republica

May 14, 2025

Nepali organization selected for research in China

The China-Nepal Friendship Medical Research Center of Professor Rajiv Kumar Jha, established at Xi’an Medical University in Xi’an, China, has been selected for the research institute convened by the Chinese government.

Rajiv Kumar Jha: Nepal’s Enduring Diplomatic Bridge to China

Nepal Diplomat

May 14, 2025

Rajiv Kumar Jha: Nepal’s Enduring Diplomatic Bridge to China

In China, where trust is difficult to come by, a scholar from Nepal has defied the odds. Anyone familiar with the diplomatic arena knows how difficult it is to establish true trust with Chinese officials.

Shaanxi Province University Youth Innovation Team — Nepal Traditional Medicine Anti-tumor Basic Translation Research Innovation Team

xiyi

March 12, 2025

Shaanxi Province University Youth Innovation Team — Nepal Traditional Medicine Anti-tumor Basic Translation Research Innovation Team

The Nepalese traditional medicine anti-tumor basic transformation research innovation team is based on the Sino-Nepalese Friendship Rajim Medical Laboratory of the School of Clinical Medicine. Professor Rajim, a high-level foreign expert from Nepal, serves as the team leader. The team is composed of young doctors in clinical medicine, pharmacology, cell biology, materials science and other majors. Guided by clinical problems, basic and medical-engineering scientific research is carried out, focusing on the research on the anti-tumor mechanism of Nepalese traditional medicine and the development of tumor diagnosis and treatment products and new drugs. In the past five years, more than 50 projects have been approved by the National Natural Science Foundation, the State Administration of Foreign Experts Affairs, the key industrial chain of the Shaanxi Provincial Department of Science and Technology, the Shaanxi Provincial Department of Education, and the Shaanxi Provincial Association for Science and Technology. More than 60 high-level academic papers have been published, and the backbone members of the team have guided more than 40 students in subject competitions, and won the excellent results of the China International Innovation and Entrepreneurship Competition National Competition Bronze Award.

Rajim: We must raise China-Nepal exchanges to “8848 meters”

November 7, 2024

Rajim: We must raise China-Nepal exchanges to “8848 meters”

In the 18 years since he came to China, he has traveled back and forth between Shaanxi and Nepal, working hard to sew and strengthen the friendly exchanges between the two countries.

With his fluent Mandarin and occasional non-standard Shaanxi dialect, it is hard to associate Rajiv Kumar Jha with the identity of a “foreigner”. Rajiv comes from Nepal, a colorful place on the “Silk Road”, but considers himself a “Shaanxi native”. His favorite thing to do is to meet up with a few friends to eat steamed buns, kebabs, and drink Hans…

‘China wants Nepal to implement agreements’

thehimalayantimes

October 3, 2023

‘China wants Nepal to implement agreements’

China is waiting for implementation of bilateral agreements and memorandum of understandings with Nepal that were inked during the recent official visit of Prime Minister Pushpa Kamal Dahal, said Rajib Kumar Jha, a Nepali professor in China.

“Shared commitments in the joint statement along with the agreements and memorandum of understanding reached between Nepal and China during the visit of PM Dahal are in the welfare and development of Nepal and they are good. However, China is also waiting for their implementation in the context of non-implementation of such agreements in the past,” said Prof Jha. The cross border railway agreement reached during the visit of the PM is important for Nepal, he viewed. “It will not take time for Beijing’s prosperity to reach Kathmandu if the Nepal-China cross border railway is constructed. Be they tourists or goods of China, they can reach Nepal in five or six days from any place of China. It is not enough for a landlocked country like Nepal to connect through the air. It will hugely benefit Nepal if it connects with the railway.

China wants to bring the railway to Nepal. But for this, we are the ones who lobby diplomatically,” he said.

Recalling past agreements and memorandum of understandings reached between the two countries on the issue of connecting Nepal through the railway, he said this would additionally help in the development of the tourism sector of Nepal. If Nepal wants to take maximum advantags from the prosperity of neighbouring China, the most reliable option is the railway system, he said.

China wants Nepal to implement agreements: Prof Dr Jha

MyRepublica

October 2, 2023

China wants Nepal to implement agreements: Prof Dr Jha

China is waiting for the implementation of bilateral agreements and memorandum of understandings with Nepal that took place during the recent official visit of Prime Minister of Nepal Pushpa Kamal Dahal ‘Prachanda’, said Dr Rajib Kumar Jha, a Nepali professor in China.

“Shared commitments in the joint statement along with the agreements and memoranda of understanding reached between Nepal and China during the visit of PM Dahal to China are in the welfare and development of Nepal and they are good. However, China is also waiting for their implementation in the context when such agreements could not implement in the past,” said Prof Jha.

The cross border railway agreement reached during the visit of the PM is important for Nepal, he is of the view. “It does not take time for Beijing’s prosperity to reach Kathmandu if the Nepal-China cross border railway is constructed. Be them tourists or goods of China, they can reach Nepal in five or six days from any places of China. It is not enough for a landlocked country like Nepal to connect through the air. It will hugely benefit Nepal if it connects with the railway. China wants to bring the railway to Nepal. But for this, we are the ones who lobby diplomatically,” he said.

Recalling past agreements and memorandum of understandings reached between the two countries on the issue of connecting Nepal through the railway, he said this would additionally help in the development of the tourism sector of Nepal. If Nepal wants to take maximum advantages from the prosperity of neighbouring China, the most reliable option is the railway system, he said.

China Urges Nepal to Implement Agreements: Prof Dr. Jha

nepalnews

October 2, 2023

China Urges Nepal to Implement Agreements: Prof Dr. Jha

China is waiting for the implementation of bilateral agreements and memorandum of understandings with Nepal that took place during the recent official visit of Prime Minister of Nepal Pushpa Kamal Dahal, said Dr Rajib Kumar Jha, a Nepali professor in China.

“Shared commitments in the joint statement along with the agreements and memoranda of understanding along with reached between Nepal and China during the visit of PM Dahal to China are in the welfare and development of Nepal and they are good. However, China is also waiting for their implementation in the context when such agreements could not implement in the past,” said Prof Jha.

The cross border railway agreement reached during the visit of the PM is important for Nepal, he is of the view. “It does not take time for Beijing’s prosperity to reach Kathmandu if the Nepal-China cross border railway is constructed. Be them tourists or goods of China, they can reach Nepal in five or six days from any places of China. It is not enough for a landlocked country like Nepal to connect through the air. It will hugely benefit Nepal if it connects with the railway. China wants to bring the railway to Nepal. But for this, we are the ones who lobby diplomatically,” he said. https://nepalnews.com/s/nation/china-urges-nepal-to-implement-agreements-prof-dr-jha/

Focusing on the people, we will work together towards the future

November 11, 2022

Focusing on the people, we will work together towards the future

History shows that the Communist Party of China (CPC) is firmly guiding the Chinese people toward realizing the great change of the country from standing up and being rich to becoming strong. It has advanced reform, opening-up, and socialist modernization over the previous years, giving the country more reliable institutional and material grounds for pursuing its objective of national rejuvenation.
Focusing on the people, we will work together towards the future

weixin

November 11, 2022

Focusing on the people, we will work together towards the future

History shows that the Communist Party of China (CPC) is firmly guiding the Chinese people toward realizing the great change of the country from standing up and being rich to becoming strong. It has advanced reform, opening-up, and socialist modernization over the previous years, giving the country more reliable institutional and material grounds for pursuing its objective of national rejuvenation.

Prof Dr Jha wins prestigious award in China

Makalukhabar

May 4, 2022

Prof Dr Jha wins prestigious award in China

KATHMANDU: The Shaanxi Provincial Government of China has decided to present the “Three Qin Friendship Award” for the year 2022 to Nepali professor Dr Rajiv Kumar Jha.

The award is the highest award established by the provincial government to commend foreign experts who have made outstanding contribution to the economic and social development of Shaanxi.

The award is to be presented to various distinguished personalities from 10 countries including Jha.

Other awardees are from the United States of America, the UK, Canada, Russia, Germany, South Korea, Switzerland, the Netherlands and Serbia.

The award is given to those foreign personalities in Shaanxi Province contributing to the sectors of economy, social, science and technology, health and culture in China and to the promotion of relations between China and the countries they represent.

The award which was presented every two years since 1999 is now awarded every year from 2015.

According to Xi’an Medical University of China, the winners were selected among professors, researchers, medical professionals, scientists and entrepreneurs from different parts of the globe who are currently in Shaanxi.

Prof Dr Jha is with the University and is engaged in teaching and research projects.

Nepal failed to garner support from China, this time again: Dr. Rajiv Jha

enewspolar

March 27, 2022

Nepal failed to garner support from China, this time again: Dr. Rajiv Jha

Nepal-China relations expert Dr. Rajiv Kumar Jha has said that Nepal has failed to garner broader support from the top Chinese diplomat, Chinese Foreign Minister Wang Yi.

After visiting Afghanistan and India, Chinese Foreign Minister and State Councillor Wang Yi arrived in Nepal on Friday for a three-day visit. The visit was expected to be more successful and fruitful, and experts believed that there would be signing of some infrastructure projects under BRI, a flagship program of Chinese government.

But Nepal government found not so much interested on China-funded BRI projects, which covered infrastructure activities including roads, bridges, airports, railways, hydropower generation, among others.

Nepal can get vaccine easily from China: Prof. Rajiv Jha

Everest Times

January 4, 2021

Nepal can get vaccine easily from China: Prof. Rajiv Jha

Professor Doctor Rajiv Kumar Jha has been teaching medical sciences in a university in China for about two decades since he did Ph.D. and then postdoctoral in minimizing the outbreak of gall bladder cancer from a Chinese university. China’s Shaanxi provincial government has established ‘China Nepal Friendship Medical Research Center of Professor Rajiv Kumar Jha’ in Xi’an Medical University in honour of Prof. Jha. Founded five years ago, the research center conducts studies on cancer and facilitates exchanges of medical experiences between Nepal and China. Prof. Jha has been a visiting medical professor in different universities in China.

“I want to return to Xi’an” Dr Rajiv Jha

Enewspolar

February 15, 2020

“I want to return to Xi’an” Dr Rajiv Jha

Rajiv Kumar Jha, a professor at Xi’an Medical University, smiles after handing over more than 10 hard-won boxes of medical supplies to Chinese personnel preparing for the construction of an international airport in Butwal, southern Nepal, at around 5pm local time on February 12.

Rajiv, a 41-year-old Nepalese specialist, has spent more time in China than in Nepal. When he was 17, he came to Xi’an with a medical dream. He was pleasantly surprised to find that in the long history of friendly exchanges between the two countries, Xi’an was a city that could not be left unexplored: Fa Xian of the eastern Jin dynasty and Xuan Zang of the Tang dynasty both crossed the Himalayas from here to Lumbini, Nepal, the birthplace of Sakyamuni, from which they translated many buddhist classics that are still extant today.

XMU Foreign Expert Receives Chinese Permanent Residence Card

November 12, 2019

XMU Foreign Expert Receives Chinese Permanent Residence Card

To recognize his contribution to medical research and China-Nepal friendship, Xi’an Medical University professor Rajiv Kumar Jha is granted Chinese Permanent Residence Card by Exit-Entry Administration of Xi’an Public Security Bureau. Director Song Yang of the Bureau and Party Secretary Fan Bing of XMU attend the ceremony to witness the moment.

Nepal Gears Up for Constitution Day 2019 in Full Swing

NepaliSansar

September 20, 2019

Nepal Gears Up for Constitution Day 2019 in Full Swing

Meanwhile, the Nepal Government has honored Professor Dr. Rajiv Kumar Jha with the Prabal Janasewashree Award on the occasion of Constitution Day.

Dr. Jha was awarded the honor for his contribution to the Nepal ‘research field’.

The research professor is the Director of the China-Nepal Friendship Medical Research Center of Professor of Rajiv Kumar Jha in China’s Shiyan Medical University.

The Chinese Government had established the research center in Jha’s name at a cost of NPR 50 million.

Interestingly, Nepal PM KP Sharma Oli inaugurated the research center on his first official China visit.

Rajiv Kumar Jha bags Prabal Janasewashree award

khabarhub

September 20, 2019

Rajiv Kumar Jha bags Prabal Janasewashree award

The government has honored Professor Dr Rajiv Kumar Jha with ‘Prabal Janasewashree’ award on the occasion of Constitution Day on Friday.

Jha received this coveted award for his contribution to the research field.

Jha, who is based in China for the last 23 years, is the director of China-Nepal Friendship Medical Research Center of Professor of Rajiv Kumar Jha, established in Xi’an Medical University in China.  The China government had established this center in Jha’s name at the cost of Rs 50 million.

Prime Minister KP Sharma Oli had inaugurated the research center during his first official visit to China.

China’s Shanxi Province in 2015 had conferred a ‘100 Talent’ tile on Jha as a youth scientist.

High-level visit from China will take place this year: Dr Rajiv Jha

khabarhub

February 4, 2019

High-level visit from China will take place this year: Dr Rajiv Jha

Dr Rajiv Kumar Jha, who originally hails from Dhanusha district, is the director of Nepal Friendship Medical Research Center. Dr Jha has been taking a close look at the Nepal-China relations for the past 20 years. Khabarhub recently talked to Jha on the Nepal-China partnership, Belt and Road Initiative (BRI), and the development issue of Nepal while maintaining balance with India. Excerpts of the interview:

Khabarhub: Speculations are rife about a high-level visit from China this year. When do you think it will take place?

Dr Jha: China will send a high-level delegation to Nepal this year. Most probably, Chinese President Xi Jinping will embark on an official visit to Nepal in the middle of this year. Nepal has to start making necessary preparations to reap benefits from the historic visit.

Professor Rajim, a distinguished expert of Shaanxi Province’s “Hundred Talents Program”, was hired as an international project consultant and researcher of our institute

weixin

August 1, 2017

Professor Rajim, a distinguished expert of Shaanxi Province’s “Hundred Talents Program”, was hired as an international project consultant and researcher of our institute

On August 1, 2017 , Rajiv Kumar Jha , a specially appointed expert of Shaanxi Province’s “Hundred Talents Program” and professor of Xi’an Medical College, was hired as an international project consultant and researcher of Shaanxi Institute of Innovative Talent Development.

拉吉姆:要让中尼交流升到“8848米”

weixin

September 22, 2015

拉吉姆:要让中尼交流升到“8848米”

来中国18年,他往返穿梭于陕西、尼泊尔之间,用心将两国友好交流关系缝接、织密。

一口流利的普通话,加上时不时冒出几句不太标准的陕西方言,让人很难将拉吉姆(Rajiv kumar jha)与“老外”这一身份联系起来。拉吉姆来自“丝绸之路”上的多彩之地尼泊尔,却自认是“陕西人”,最爱做的事情是约上三五好友,一起咥泡馍、吃烤串、喝汉斯……

“我热爱中国,这里是我的第二故乡。”35岁的拉吉姆,有一大半的人生轨迹都在中国:17岁只身来到中国求学,毕业后留在西安工作,一呆就是18年;读书时,他是西安交通大学优秀博士生,工作后成了西安医学院最年轻的教授。在尼泊尔,拉吉姆是首位青年学者奖获得者,也是第一位特聘于陕西省“百人计划”的专家学者。

此外,常年穿梭于中国、尼泊尔两国之间,飞行里程数加起来能绕地球近4圈的拉吉姆还有一个“非官方”身份——“中尼友好使者”。他有一个“中国梦”:用心将中尼两国友好交流缝接起来,让接线更密集、更悠长……

40 projects were funded by the second batch of foreign young scholars research fund in 2010

Ebiotrade

October 12, 2010

40 projects were funded by the second batch of foreign young scholars research fund in 2010

The review of the second batch of 2010 Young Foreign Scholars Research Fund applications has been completed, and a total of 40 applicants have been funded. The specific project list is as follows:

Latest Video

Explainer

May 14, 2025

नुन नै बिदेश को खान्छौं, कसरी स्वदेशको माया लागोस त ? Dr Rajiv Jha on Tamasoma Jyotirgamaya

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December 20, 2022

Foreigners in Shaanxi Episode One – Rajiv kumar jha

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Interview

August 21, 2017

Prof. Dr. Rajiv Kumar Jha in POWERchat with Laxman D. Pant

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August 16, 2015

Avenues @ Health (Dr. Rajiv Kr. Jha – health sector in Nepal)

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Publications

Innovative Solutions to Complex Medical Challenges: Dr. Jha’s Research Publications

west
east

HealthCare

February 4, 2020

Dual Loading of Nanoparticles with Doxorubicin and Icotinib for the Synergistic Suppression of Non-Small Cell Lung Cancer

Background: Combination chemotherapy plays an important role in the clinical therapy of non-small cell lung cancer (NSCLC). However, the pharmacokinetic differences between drugs are an insurmountable barrier in traditional treatment. For the synergistic therapy of NSCLC, synergistic nanoparticles (EDS NPs) loaded with both an EGFR inhibitor and doxorubicin (DOX) were designed and prepared.

Methods: Erlotinib, apatinib and icotinib were evaluated for optimal combination with DOX in treatment of NSCLC via CCK-8 assay. Then the cationic amphipathic starch (CSaSt) and hyaluronic acid (HA) were applied to coencapsulate DOX and EGFR inhibitor to form the EDS NPs. EDS NPs were evaluated in NSCLC cell lines (A549, NCI-H1975 and PC9) and NSCLC xenograft mouse models.

Results: Icotinib was found to be the optimal synergistic drug in combination with DOX in the tested. Subsequently, icotinib and DOX were coencapsulated in the NPs. EDS NPs were roughly spherical with an average size of 65.7±6.2 nm and possessed stable loading and releasing properties. In the in vitro investigation, EDS NPs could efficiently deliver payloads into cells, exhibited cytotoxicity and produced strong anti-migration properties. In vivo hypotoxicity was confirmed by acute toxicity and hemolytic assays. The in vivo distribution showed that EDS NPs could enhance accumulation in tumors and decrease nonspecific accumulation in normal organs. EDS NPs significantly promoted the in vivo synergistic effects of icotinib and DOX in the mouse model.

Conclusions: The study suggests that EDS NPs possess noteworthy potential for development as therapeutics for NSCLC clinical chemotherapy.

Keywords: non-small cell lung cancer, combination chemotherapy, nanoparticles, icotinib, doxorubicin

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HealthCare

December 18, 2019

Docetaxel and Doxorubicin Codelivery by Nanocarriers for Synergistic Treatment of Prostate Cancer

Combination chemotherapy has been proven to be an efficient strategy for the treatment of prostate cancer (PCA). However, the pharmacokinetic distinction between the relevant drugs is an insurmountable barrier to the realization of their synergistic use against cancer. To overcome the disadvantages of combination chemotherapy in the treatment of PCA, targeted nanoparticles (NPs), which can codeliver docetaxel (DOC) and doxorubicin (DOX) at optimal synergistic proportions, have been designed. In this study, the DOC and DOX codelivery nanoparticles (DDC NPs) were constructed by hyaluronic acid (HA) and cationic amphipathic starch (CSaSt) through a self-assembly process. Human PCA cell lines (PC-3, DU-145, and LNCap) and mouse models were then used for evaluation in vitro and in vivo, respectively, of delivery and antitumor effects. The DDC NPs were spherical with rough surfaces, and the size and zeta potential were 68.4 ± 7.1 nm and -22.8 ± 2.2 mV, respectively. The encapsulation efficiencies of DOC and DOX in the NPs were 96.1 ± 2.3% and 91.4 ± 3.7%, respectively, while the total drug loading was 9.1 ± 1.7%. Moreover, the ratio of DOC to DOX in the DDC NPs was approximately 1:400, which aligned with the optimal synergistic proportions of the drugs. The DDC NPs exhibited excellent loading capacities, performed sustained and enzymatic release, and were stable in PBS, medium, and serum. After investigations in vitro, the DDC NPs were as effective as the dual drug combination in terms of cytotoxicity, antimigration, and apoptosis. Internalization results indicated that the DDC NPs could effectively deliver and fully release the payloads into PCA cells, and the process was mediated by the ligand-receptor interaction of HA with the CD44 protein. Low toxicity in vivo was confirmed by acute toxicity and hemolytic assays. The distribution in vivo showed that DDC NPs could enhance the accumulation of drugs in tumors and decrease nonspecific accumulation in normal organs. More importantly, DDC NPs significantly promoted the curative effect of the DOC and DOX combination in the PCA cell xenograft mouse model, indicating that the drugs with NPs did indeed act synergistically. This study suggests that the DDC NPs possess noteworthy potential as prospects for the development of PCA clinical chemotherapy.

https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.01436/full

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July 16, 2014

Sorafenib Inhibition of Hepatic Stellate Cell Proliferation in Tumor Microenvironment of Hepatocellular Carcinoma: A Study of the Sorafenib Mechanisms

We investigated the mechanism and effects of sorafenib on hepatic stellate cell (HSC) viability and in the liver tumor microenvironment. The expression of α-smooth muscle actin (α-SMA) was measured immunocytochemically in the LX2 cells treated with differing concentrations of sorafenib. Changes in the platelet-derived growth factor (PDGF)-BB and tumor growth factor (TGF)-β1 concentrations were detected in the LX2 supernatant using an enzyme-linked immunosorbent assay (ELISA). Expressions of the extracellular signal-regulated kinase 1 (ERK1), ERK2, and Akt signaling pathways were measured using a western blot assay. The LX2 cells were cocultured with HepG2 cells for 24 h to observe their effects on HepG2 cell invasive ability.

(1) After treatment with various concentrations of sorafenib for 12, 24, 36, or 48 h, MTT assay showed that the viability of the treated LX2 cells was lower than in the controls.

(2) As sorafenib concentration and time of exposure increased, α-SMA expression became weaker in the treated cells.

(3) The PDGF-BB and TGF-β1 concentrations decreased with higher concentration, and longer exposures under the same sorafenib concentration.

(4) The ERK1, ERK2, and Akt expressions were identical between the treated and the control groups, but their phosphorylated expression decreased with increased concentrations of sorafenib.

(5) The invasive ability of the HepG2 cells induced by the LX2 gradually decreased as sorafenib concentrations increased. Sorafenib suppressed α-SMA expression, inhibited PDGF-dependent signaling pathways in HSCs, downregulated the PDGF-BB and TGF-β1 expression in the HSCs supernatant, and restrained viability of the HSCs, resulting in suppressed proliferation and invasion in the HepG2 cells.

 

https://pubmed.ncbi.nlm.nih.gov/24633454/

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HealthCare

October 7, 2013

Current status of percutaneous vertebroplasty and percutaneous kyphoplasty – a review

Percutaneous vertebroplasty (PV) and kyphoplasty (PK) are the 2vertebral augmentation procedures that have emerged as minimally invasive surgical options to treat painful vertebral compression fractures (VCF) during the last 2 decades. VCF may either be osteoporotic or tumor-associated. Two hundred million women are affected by osteoporosis globally. Vertebral fracture may result in acute pain around the fracture site, loss of vertebral height due to vertebral collapse, spinal instability, and kyphotic deformity. The main goal of the PV and PK procedures is to give immediate pain relief to patients and restore the vertebral height lost due to fracture. In percutaneous vertebroplasty, bone cement is injected through a minimal incision into the fractured site. Kyphoplasty involves insertion of a balloon into the fractured site, followed by inflation-deflation to create a cavity into which the filler material is injected, and the balloon is taken out prior to cement injection. This literature review presents a qualitative overview on the current status of vertebral augmentation procedures,especially PV and PK, and compares the efficacy and safety of these 2 procedures. The review consists of a brief history of the development of these 2 techniques, a discussion on the current research on the bone cement, clinical outcome of the 2 procedures, and it also sheds light on ongoing and future research to maximize the efficacy and safety of vertebral augmentation procedures.

Keywords: Bone Cements – therapeutic use, Fractures, Compression – surgery, Kyphoplasty – trends, Spinal Fractures – surgery, Surgical Procedures, Minimally Invasive – trends, Vertebroplasty – trends

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HealthCare

August 1, 2013

Advances in diagnosis and treatment of hilar cholangiocarcinoma – A review

Hilar cholangiocarcinoma (HC) is a rare tumor that causes devastating disease. In the late stages, this carcinoma primarily invades the portal vein and metastasizes to the hepatic lobes; it is associated with a poor prognosis. HC is diagnosed by its clinical manifestation and results of imaging techniques such as ultrasound, computed tomography, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiography, and percutaneous transhepatic cholangiography. Preoperative hepatic bile drainage can improve symptoms associated with insufficient liver and kidney function, coagulopathy, and jaundice. Surgical margin-negative (R0) resection, including major liver resection, is the most effective and potentially curative treatment for HC. If the tumor is not resected, then liver transplantation with adjuvant management can improve survival. We conducted a systematic review of developments in imaging studies and major surgical hepatectomy for HC with positive outcomes regarding quality of life.

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August 1, 2013

Kyphoplasty for the Treatment of Pain Distant to Osteoporotic Thoracolumbar Compressive Fractures

Vertebral fractures are one of the most common osteoporotic fractures. We sought to investigate the incidence of distant pain after osteoporotic vertebral compressive fracture (OVCF) at the thoracolumbar junction, and to explore the effect of kyphoplasty in the treatment of distant pain post-OVCF. Eighty-seven patients diagnosed OVCF between T11 and L2 were included in the study. The region of pain and its proximity to the thoracolumbar compressive fracture was recorded. For pain management, all patients received kyphoplasty. The follow-up period was every 3 months for 1-year post-surgery. The Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) were used pre-operatively, post-operatively, and at 3-, 6-, and 12-month follow-ups to assess patient status. All patients completed the operation, with 72 patients having focal pain over the compression fracture. Eleven cases also had pain distal to the fracture region in the following areas: lower back, near the iliac crest (n = 6), the groin (n = 3), and the trochanteric region (n = 2). Four cases had pain in distant to the fracture: lower back, near iliac crest (n = 3), and the trochanteric region (n = 1). All patients had a significant improvement in clinical symptoms. The average VAS and the ODI decreased significantly pre-operatively to post-operatively (p < 0.05). In addition to focal tenderness, many patients with thoracolumbar compression fractures may have pain distant to the fracture. This can be successfully treated using kyphoplasty. This phenomenon also indicates that patients at risk of osteoporosis who also have lower back pain should not neglect the potential for a thoracolumbar fracture.

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HealthCare

April 2, 2013

Resveratrol Suppresses Microcirculatory Disturbance in a Rat Model of Severe Acute Pancreatitis

The present study sought to understand the mechanisms of attenuation of severe acute pancreatitis (SAP) by resveratrol (RES). SAP was experimentally induced in rats by injection of 4 % sodium taurocholate in the retrograde pancreatic duct. Three study groups were evaluated: Group I (sham-operated animals), Group II (SAP animals), and Group III (SAP animals treated with RES at 20 mg/kg/body weight, 5 min after induction of SAP). The study outcomes were histopathologic changes and alterations in biochemical markers: plasma renin activity and levels of angiotensin II, endothelin, and nitric oxide in plasma. Biochemical markers were evaluated at 3, 6, and 12 h after induction of SAP. SAP was associated with significant (p < 0.05) histopathologic changes (saponification spots in the intraperitoneal cavity, severe pancreatic edema, blood congestion, varying degrees of necrosis, etc.), as well as with elevation of biochemical markers in blood plasma. RES treatment significantly (p < 0.05) attenuated changes of both histopathologic and biochemical markers induced by SAP. In conclusion, this study provides evidence that RES treatment is a promising therapeutic approach to suppress microcirculatory disturbance in SAP.

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